Pharmacists tend to ask if a substitute or generic brand is ok for a prescription. While I’m generally for that as it tends to save money, I’d recommend against saying yes when it comes to depression-related medication. As you know, getting the dosage right is tricky enough. From my past personal experience, substitutes didn’t work or at least worked differently, thus messing with my head – so basically, once you get to something that works for you (whichever brand that might be), don’t risk messing with it for the sake of saving a few dollars. You can also ask your doctor to put a tick in the “no substitutes” box on the prescription, then the pharmacist won’t even go there.